People mostly use that expression in the conditions below.
First one is when they get bored, dislike something, or become sad. It is like the expression "Ugh!" or to sigh.
For example: Off! Başım ağrıyor... (Ugh! I´ve got a headache)
Second one is the opposite. When they like something a lot, become very happy or enjoy. It is like the expression "Wow!" when you like something.
For example: Off! Şu arabaya bak! (Wow! Look at that car!)
In addition, it is also used when people get hurt, or get tired.
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