Meaning and Use:

We use this form when there is a obstacle to do something or ´what we do´ does not help ,so usually it is follwed by negative sentences like the following samples;

istemesine istiyorum da/ama param yok

Actually I want it but I don´t have money

We could just say ´istiyorum´/´I want´ but the difference is that it sounds like the speaker really wants it but the only reason is lack of money and he is helpless when we say ´istemesine istiyorum´

The grammar:

iste-mek

iste-mesine

when the verb stem (it is iste- here) has either e,i,ö or ü as last vowel (here the last vowel is e, iste) we add -mesine for all subjects (ben,sen ...)

yap-mak

yap-masına

when the verb stem has either a,ı,o or u we add -masına

this first word is always same for all subjects and in all tenses.

But when you use it with the other tenses you just change the second verb that you use as usual.

istemesine istiyorum ama - I want it but 

istemesine istedim ama - I wanted it but

For more examples and information, you may like to see this link;

http://www.learnturkisheasy.com/phrases/mesineinturkish

Blogger, nice help thanks.

I´d like to add bit more on bloggers wonderful explanation.

It is also used to strengthen and emphasize the action by repeating it. [  verb + mAsına + Verb + tense ending + personal ending]

It can also used with conjunction ´dA´ which functions as "ama" [but,however]

Çalışmasına çalışıyor da cebinde beş parası yok.

He is [so called] working but he hasn´t got a penny in his pocket.

* there is a sarcasm in the statement. [so called]

* there is emphesis on his working

* there is hidden ´although´ ,"despite" ---> Although he is working  he hasn´t got a penny in his pocket.

btw I liked your website blogger. nice job.